Source Themes

Type 2 Diabetes Subtype Responsive to ACCORD Intensive Glycemia Treatment

OBJECTIVE. Current type 2 diabetes (T2D) management contraindicates intensive glycemia treatment in patients with high cardiovascular disease (CVD) risk and is partially motivated by evidence of harms in the Action to Control Cardiovascular Risk in …

Large-Scale Meta-Analysis of Potential Biomarkers for Treatment Response to Anti-PD-1/PD-L1 Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICIs) blocking programmed death receptor 1 or its ligand (anti-PD-1/PD-L1) are a burgeoning class of promising cancer treatments. However, not all patients respond to these treatments. Although studies have suggested …

Neoadjuvant chemoradiation improves oncologic outcomes in low and mid clinical T3N0 rectal cancers

BACKGROUND. Controversial data exists in the current literature in regard to the use of neoadjuvant chemoradiation (nCRT) in patients with clinical T3N0 (cT3N0) rectal cancers, specifically based on location and relation to peritoneal reflection. We …

Multiple Primary Cancer: Associations and Network Link Analysis

Cancer survivors are considered at increased risk of developing new primary cancers. The Surveillance, Epidemiology and End Results (SEER) Program monograph reports that about 10% of cancer survivors in the USA were diagnosed with a second or …

Relationship of Epistemic Beliefs and Sociopolitical Attitudes